5'-nucleotidase

5′-nucleotidase

[no̅o̅′klē·ot′idās]
an enzyme, elevated in some liver disorders and cancer of the pancreas. It is infrequently measured in the blood to diagnose certain liver and bone diseases. This enzyme is widely distributed throughout the body but is found in high concentrations in the liver and pancreas. The normal accumulation in serum is 0.1 to 6 units.

5'-nucleotidase

An enzyme present in the serum in abnormal amounts in diseases that affect the liver or obstruct the biliary tree.
Synonym: 5'- Ntase.
References in periodicals archive ?
However, ratio of dCK and cytosolic 5'-nucleotidase II (cN-II), which inactivates Ara-C by dephosphorylation, has been shown to predict ara-C sensitivity.
Short-term zinc supplementation in women with non-insulin-dependent diabetes mellitus: effects on plasma 5'-nucleotidase activities, insulin-like growth factor I concentrations, and lipoprotein oxidation rates in vitro.
Lipid peroxidation is followed by loss of structural integrity of plasma membranes thereby releasing the membrane associated enzymes like Adenosine deaminase and 5'-nucleotidase into the circulation.
5'-nucleotidase is an intrinsic membrane glycoprotein, present as an ectoenzyme in a wide variety of mammalian cells and it hydrolyzes extracellular AMP to adenosine and represents the major control point for extracellular adenosine levels and is a regulator of the adenosine signaling pathway.
s case of pyrimidine 5'-nucleotidase deficiency and heterozygous [alpha]-thalassemia was an interesting co-existence (1).
In the second assay, 5'-Nucleotidase activity was determined using the [[sup.
5'-nucleotidase activity is altered by hypo- and hyperthyroidism in platelets from adult rats.
5'-Nucleotidase and [gamma]-glutamyl-transferase activity are used to confirm liver-specific origin of alkaline phosphatase.
Each of the thiopurine riboside monophosphates (TIMP, thioguanosine monophosphate, and methyl-TIMP) can be converted into thiopurine ribonucleotide triphosphates (8, 9) and dephosphorylated into thiopurine ribonucleosides [mercaptopurine riboside (rMP), mercaptoguanosine riboside (rTG), and MMP riboside (rMMP)] by 5'-nucleotidase (10, 11).
For this reason, it is often useful to measure another enzyme not found in these organs, either the 5'-nucleotidase (5'-NT) or the gamma-glutamyl transpeptidase (GGTP), along with the alkaline phosphatase when the origin of the elevated alkaline phosphatase (normal < 115 IU/1) is not clear.
Reliability of serum 5'-nucleotidase alkaline phosphatase and liver scan in hepatic metastasis.