4-methylpyrazole

4-methylpyrazole

(mĕ-thĭl-pĭr′ă-zōl)
An intravenous antidote for ethylene glycol poisoning.

4-methylpyrazole

an inhibitor of alcohol dehydrogenase, used in the treatment of ethylene glycol poisoning.
References in periodicals archive ?
Use of 4-methylpyrazole was also greater in the inhalation group (24%) than in the ingestion group (20%).
Isoniazid potentiation of acetaminophen hepatotoxicity in the rat and 4-methylpyrazole inhibition of it.
4-methylpyrazole, have been used to treat ethylene glycol poisoning in humans [69,70].
Treatment of ethylene glycol poisoning with intravenous 4-methylpyrazole.
Raptor" or the "Company") (BULLETIN BOARD: RPTP) , today announced positive results in its Phase IIa study of oral 4-methylpyrazole ("4-MP") in subjects with ALDH2 deficiency, or ethanol intolerance, as the initial development stage of its Convivia(TM) program.
Bennu"), has initiated the Company's first clinical-stage program after dosing the first cohort in a Phase IIa study of oral 4-methylpyrazole ("4-MP") in subjects with ALDH2 deficiency, or ethanol intolerance, as the initial development stage of its Convivia(TM) program.
Compounds other than alcohol also are very good inducers of CYP2E1, including 4-methylpyrazole, a drug now used for the treatment of methanol and ethylene glycol poisoning.
Under terms of the agreement, Patheon will provide Bennu's proprietary oral formulation of 4-methylpyrazole ("4-MP") for usage in clinical studies, which Bennu plans to initiate in the second half of 2008.
Antizol-Vet, commonly known as 4-methylpyrazole or 4MP, prevents the metabolism of ethylene glycol to its toxic metabolites through the inhibition of the enzyme alcohol dehydrogenase.
The treatments were a urease inhibitor (Agrotain; N-(n-butyl) thiophosphoric triamide), 2 nitrification inhibitors (dicyandiamide, DCD; 4-methylpyrazole, 4MP), a combination (DCD+Agrotain), a urine control, and a nil urine.
The company's other clinical-stage product candidates comprise Convivia, an oral formulation of 4-methylpyrazole for the treatment of acetaldehyde toxicity resulting from aldehyde dehydrogenase deficiency.
Raptor" or the "Company") (OTC Bulletin Board: RPTP), today announced positive results in its Phase IIa study of oral 4-methylpyrazole ("4-MP") in subjects with ALDH2 deficiency, or ethanol intolerance, as the initial development stage of its Convivia(TM)