4-ipomeanol

4-ipomeanol

a furanoterpene produced in sweet potatoes (Ipomoea batatus) by the fungus Fusarium solani (F. javanicum) which has the effect of damaging pulmonary epithelium and producing lesions characteristic of atypical interstitial pneumonia in cattle which consume moldy sweet potatoes. The toxin is produced from furanosesquiterpenoid phytoallexins.
References in periodicals archive ?
Despite lower levels of CYP450 activity in immature neonatal Clara cells, these cells were more susceptible to injury at lower doses of 4-ipomeanol than adult cells (Plopper et al.
Elevated susceptibility to 4-ipomeanol cytotoxicity in immature Clara cells of neonatal rabbits.
Neonatal Clara cell toxicity by 4-ipomeanol alters bronchiolar organization in adult rabbits.