4-hydroxy proline

hydroxyproline /hy·droxy·pro·line/ (-pro´lēn) a hydroxylated form of proline, occurring in collagen and other connective tissue proteins.

hy·drox·y·pro·line (h

-dr

-pr

)

An amino acid produced during the hydrolysis of collagen.

hydroxyproline

[-prō′lēn]

an amino acid whose level in the urine is elevated in diseases of the bone and certain genetic disorders, such as Marfan's syndrome. Its normal accumulation in urine after a 24-hour collection is 10 to 75 mg.

hydroxyproline [hi-drok″sĭ-pro´lēn]

an amino acid produced in the digestion of hydrolytic decomposition of proteins, especially of collagens.

hydroxyproline

Hyp; an amino acid derived from proline.

hydroxyproline

Biochemistry A hydroxylated amino acid which is most concentrated in collagen ↑ in urine Indicates ↑ turnover of bone matrix, often caused by osteoporosis ↓ in Malnutrition, ↑ by acromegaly, acute osteomyelitis, burns, congenital hyperphosphatasia, fibrous dysplasia, healing fractures, hyperparathyroidism, hyperthyroidism, Marfan syndrome, osteomalacia, Paget's disease of bone, parathyroid adenoma, rickets, bone tumors

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