annexin 5

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annexin 5

A member of a highly conserved protein family that bind acidic phospholipids in a calcium-dependent manner and help flag cells destined for apoptotic death by phagocytes. Annexin 5 has a high affinity for phosphatidylserine and is transported from the inner to the outer face of the plasma membrane, where cells undergo death by apoptosis or cell necrosis. It has known anticoagulant properties and, like lactadherin, has high-affinity, PS-dependent membrane-binding-like factor VIII and factor V.