Prophylactic neuroprotective property of Centella asiatica against 3-nitropropionic acid
induced oxidative stress and mitochondrial dysfunctions in brain regions of prepubertal mice.
Moreover, PQQ protected cells from mitochondrial inhibition by rotenone, 3-nitropropionic acid
, antimycin A, and sodium azide.
11 Role of MMP-9 (Metalloproteinases) in Striatal Blood-Brain Barrier Disruption in a 3-Nitropropionic Acid
Model of Huntington's Disease 10
Further evidence that dietary intake of BM leaf powder confers the prepubertal brain with additional capacity to cope up with neurotoxic prooxidants was obtained by exposing cortical/cerebellar synaptosomes of normal and BM fed mice to 3-nitropropionic acid (3-NPA).
3-Nitropropionic acid (3-NPA), a fungal mitochondrial toxin causes selective neuronal degeneration in the striatum and produces anatomical changes similar to that of Huntington's disease in experimental animals (Brouillet et al.
Neuronal degeneration can be caused by the mitochondrial toxin 3-nitropropionic acid
(3-NPA) and produce anatomical changes similar to those in Huntington's disease.
The 12 articles here address sources of exposure ranging from recreational drugs to industrial chemicals, including MDMA (Ecstasy) and its effects on serotonin, certain pesticides and chemical warfare agents and their ability to induce muscle paralysis, local anesthetics and their possible link to ischemic injury or Alzheimer's Disease, alcohol and peripheral neuropathy, the deposition of amyloid peptides and Alzheimer's Disease, 3-nitropropionic acid
and symptoms similar to Huntington's Chorea, antineoplastic drugs and damage to the peripheral nervous system, side effects of chemotherapy, cefepime-induced encephalopathy, simulation of Parkinson's Disease, and the effects of overexposure to manganese.
To study the effect of metabolic disorder at a cellular level, we have utilized 3-nitropropionic acid
(3NP) to induce energy impairment and assess the metabolic response of two age groups to such stress.
In their shoots, the horseshoe vetch and some of its relatives build up high concentrations of a toxic, nitrogen-containing compound called 3-nitropropionic acid
Effect of lycopene and epigallocatechin-3-gallate against 3-nitropropionic acid
induced cognitive dysfunction and glutathione depletion in rat: a novel nitric oxide mechanism.
2004b), the neurotoxic mitochondrial inhibitor 3-nitropropionic acid
(Herrera-Mundo et al.
Hence in the present study we have addressed primarily two questions (i) whether dietary intake of CA leaf powder posses the propensity to modulate endogenous oxidative markers in mouse brain regions and (ii) the efficacy of CA aqueous extract to abrogate 3-nitropropionic acid
(3-NBA)-induced oxidative stress in brain mitochondria in vitro.