A highly carcinogenic hydrocarbon that can be formed chemically from deoxycholic or cholic acids, or from cholesterol; it induces the synthesis of cytochrome P-450 mRNA; the choice between 3- or 20- for the methyl group depends upon whether hydrocarbon (inner) or steroid (outer) numbering is chosen; in the latter case, the formal relationship to the cholic acids and cholesterol is clear.
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2000) Distribution and inducibility by 3-methylcholanthrene of family 1 UDP-glucuronosyltransferases in the rat gastrointestinal tract.
The aryl hydrocarbon receptor ligands 2,3,7,8-tetrachlorodibenzo-pdioxin and 3-methylcholanthrene regulate distinct genetic networks.
Poland, "An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin," Journal of Pharmacology and Experimental Therapeutics, vol.
Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a.
Hari Kumar, tested the medicines' ability to inhibit liver cancer in rats fed N'-nitrosodiethylamine (NDEA) and sarcoma in mice injected with 3-methylcholanthrene (3-MC).
Effect of interleukin-12 on tumor induction by 3-methylcholanthrene.
Regulation of cyto-chrome P450 enzymes by aryl hydrocarbon receptor in human cells: CYP1A2 expression in the LS180 colon carcinoma cell line after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 3-methylcholanthrene.
Additional control groups received one of the following treatments: saline (control); 3-methylcholanthrene (25 mg/kg, i.
Enhancing effect of quercetin on 3-methylcholanthrene carcinogenesis in C57B1/6 mice.
Studies show cancer-triggers such as 3-methylcholanthrene, found in cigarette smoke, are also concentrated in prostate fluid.
The 25 chemicals with a score of 18 are: 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, 3-methylcholanthrene, 7, 12-dimethylbenz(a) anthracene, Aldrin, benzo(a) anthracene, benzo(a) pyrene, benzo(b) fluoranthene, benzo(rst) pentaphene, Chlordane, p,p'-dichloro-diphenyl-dichloro-ethane, p,p'-dichloro-diphenyl-dichloro-ethylene, p,p'-dichloro-diphenyl-trichloro-ethane, dibenzo(a,h) anthracene, Dieldrin, Endrin, Heptachlor, hexachlorobenzene, hexachlorocyclopentadiene, hexachloraphene, kepone, mercury, Mirex, pentachlorobenzene, polychlorinated biphenyls, and toxaphene.
Two unique CYP1 genes are expressed in response to 3-methylcholanthrene treatment in rainbow trout.
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