acetyl-CoA acyltransferase

(redirected from 3-ketoacyl-CoA thiolase)

a·ce·tyl-CoA ac·yl·trans·fer·ase

an enzyme catalyzing the thioclastic cleavage by coenzyme A of β-ketoacyl-CoA, forming an acyl-CoA with a carbon chain shorter by two atoms, the missing two atoms appearing as acetyl-CoA. A step in fatty acid degradation.
See also: acetyl-CoA acetyltransferase.
References in periodicals archive ?
The mRNA expression of 3-ketoacyl-CoA thiolase (3-KAT) was increased in diabetic hearts.
The 3 enzymes involved are long-chain enoyl-CoA hydratase (LCEH), long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD), and long-chain 3-ketoacyl-CoA thiolase (LCTH).
The long-chain forms of hydratase, LCHAD, and the 3-ketoacyl-CoA thiolase exist as a multienzyme complex located in the inner mitochondrial membrane that is called the mitochondrial trifunctional protein (MTFP) (3, 4).
LCHAD activity resides in a membrane-bound multienzyme complex that also contains long-chain 3-enoyl-CoA hydratase and longchain 3-ketoacyl-CoA thiolase activities (trifunctional protein) [10,11].