HSPB1

(redirected from 28-kDa heat shock protein)

HSPB1

A gene on chromosome 7q11.23 that encodes a member of the (small) heat shock protein 20 family which is induced by environmental stress. HSPB1 plays a role in stress resistance and actin organisation; it translocates from the cytoplasm to the nucleus in response to stress. It associates with alpha- and beta-tubulin, microtubules and CRYAB, and interacts with HSPB8 and HSPBAP1.

Molecular pathology
Defects of HSPB1 cause Charcot-Marie-Tooth disease type 2F and distal hereditary motor neuropathy 2B.