25-hydroxycholecalciferol


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25-hydroxycholecalciferol

 [hi-drok″sĭ-ko″le-kal-sif´er-ol]
a metabolically activated form of cholecalciferol (vitamin D3) synthesized in the liver.

cal·ci·di·ol

(kal-sĭ-dī'ol),
First step in the biologic conversion of vitamin D3 to the more active form, calcitriol; it is more potent than vitamin D3.

25-hydroxycholecalciferol

/25-hy·droxy·cho·le·cal·cif·e·rol/ (-ko″lĕ-kal-sif´er-ol) an intermediate in the hepatic activation of cholecalciferol; as the pharmaceutical preparation calcifediol, it is used in the treatment of hypocalcemia, hypophosphatemia, rickets, and osteodystrophy associated with various medical conditions.

25-hydroxycholecalciferol

a metabolically activated form of cholecalciferol synthesized in the liver.
References in periodicals archive ?
Interactions of parathyroid hormone, 25-hydroxycholecalciferol, and 1,25-dihydroxycholecalciferol.
Heaney, RP, et al, Human Serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol.
Effect of dietary calcium, 25-hydroxycholecalciferol, or bird strain on small intestinal phytase activity in broiler chickens.
25-hydroxycholecalciferol stimulation of muscle metabolism.
The preferred test of vitamin D involves measuring the metabolite 25-hydroxycholecalciferol (25[OH]D).
Efficacy was evaluated by measuring changes in serum 25-hydroxycholecalciferol levels.
Decreased serum concentrations of 25-hydroxycholecalciferol are associated with increased risk of progression to impaired fasting glucose and diabetes.
A simple radioassay for 25-hydroxycholecalciferol without chromatography.
2006) found that in a low calcium intake model of colon cancer that genistein normalized 25-hydroxycholecalciferol 24-hydroxylase activity, part of the metabolic cycle of vitamin D homeostasis.
Lab studies in a subgroup of the subjects showed that the active treatment raised levels of 25-hydroxycholecalciferol an average of 41%, as expected.
Furthermore, because the lev-els of 25-hydroxycholecalciferol dem-onstrated in this study could occur with other recommended dosing regi-mens, the outcome of this study sug-gests that safety of high-dose vitamin D supplementation warrants further study.