alpha-ketoglutaric acid

(redirected from 2-oxoglutarate)

α-ketoglutaric acid

/α-ke·to·glu·tar·ic ac·id/ (-gloo-tar´ik) a metabolic intermediate involved in the tricarboxylic acid cycle, in amino acid metabolism, and in transamination reactions as an amino group acceptor.

α-ketoglutaric acid

2-oxoglutaric acid; intermediate of TCA cycle.
References in periodicals archive ?
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 expression in brain arteriovenous malformations and its association with brain arteriovenous malformation size.
2] and 2-oxoglutarate as substrates, is known to target HIF-1, to the 26S proteasome for degradation in normoxia.
Hydroxylysine is formed by the action of lysyl hydroxylase [procollagenlysine, 2-oxoglutarate 5-dioxygenase 1 (PLOD1)], (4) which is defective in type VI Ehlers--Danlos syndrome.
It was shown that elevated mitochondrial cholesterol levels lead to reduced 2-oxoglutarate transport and an impaired glutathione (GSH) import into mitochondria [15, 31-38].
In the second reaction, 2-oxoglutarate reacts with ammonium in the presence of glutamate dehydrogenase (GLDH) and the coenzyme NADH to produce L-glutamate, in this reaction 2 moles of NADH are oxidized to [NAD.
ATP, [alpha]-ketoglutarate (a-KG; also called 2-oxoglutarate, 2-OG), and acetyl coenzyme A (acetyl CoA)] that are co-substrates required for numerous transcriptional and epigenetic processes (e.
83 44310 Transforming growth factor beta-1 (TGF[beta]l) Spot Biological Match Peptid Difference Difference ID process score coverage between between treated/control UN/control 54751 GTP binding 135 6% [up arrow] - protein 54317 L-ascorbic acid 254 15% [down arrow] [down biosynthetic and arrow] calcium-mediated signaling 54578 Act in filament 314 25% [down arrow] [up arrow] depolymerization 54485 Involved in redox 447 22% [down arrow] [up arrow] regulation of the cell 54397 2-oxoglutarate 185 6% Appeared in meta?
Although DNA methylation mechanisms were described for several decades ago, the enzymes responsible for DNA demethylation were only discovered a few years ago: TET enzymes catalyse the conversion of 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) through a reaction requiring oxygen and 2-oxoglutarate (2OG).
1) and alanine aminotransferase (ALAT/GPT; L-Alanine: 2-oxoglutarate aminotransferase, EC: 2.
Niebisch A, Kabus A, Schultz Ch, Weil B, Bott M (2006) Corynebacterial protein kinase G controls 2-Oxoglutarate dehydrogenase activity via the phosphorylation status of the Odhl protein.
They concluded that cyanobacteria lacked the ability to make one enzyme, called 2-oxoglutarate dehydrogenase, and that this missing enzyme rendered the bacteria unable to produce a compound -- called succinyl-coenzyme A -- for the next step in the TCA cycle.