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2-naphthylamine |
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2-naphthylamine an industrial chemical identified as a urinary bladder carcinogen. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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The first such association was observed in 1895 (Rehn 1895),
and subsequent research among dyestuff workers identified the aromatic
amines benzidine and 2-naphthylamine as bladder carcinogens (Case et al. The chemicals include benzene and 2-naphthylamine, known human
carcinogens, cadmium and n-nitrosodiethanolamine, which is associated
with cancer in humans, and polonium-210, an element that emits alpha
radiation. After N-oxidation of aromatic amines such as
4-aminobiphenyl or 2-naphthylamine by CYP1A2 in the liver, O-acetylation
of the resulting hydroxylamine by NAT2 can produce unstable acetoxy
esters that decompose to form highly electrophilic aryl nitrenium ion
species. |
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