According to Keith, Thiola (tiopronin, also referred to as 2-mercaptopropionylglycine
or 2-MPG), has fewer side effects, but one of them is the depletion of the owner's bank account.
In cystinuria, cystine excretion is reduced by use of sulfhydryl-containing compounds such as 2-mercaptopropionylglycine (MPG) (6).
In this paper, we report a rapid, fully automated HPLC method for total homocysteine, cysteine, cysteinylglycine, and glutathione in plasma and urine and for drug monitoring of cysteamine in plasma and 2-mercaptopropionylglycine in urine.
L-Homocystine, L-cystine, cysteinylglycine (reduced form), glutathione (reduced form), cysteamine, 2-mercaptopropionylglycine, N-ethylmorpholine, and dithiothreitol (DTT) were obtained from Fluka Chemie; NaB[H.
Known concentrations of cysteine, cysteinylglycine, glutathione, homocysteine, cysteamine, and 2-mercaptopropionylglycine were added to plasma or urine samples.