Effect of natural products on commercial oral antidiabetic drugs in enhancing 2-deoxyglucose
uptake by 3T3-L1 adipocytes.
The compound also reportedly enhanced uptake of 2-deoxyglucose
dose-dependently in L6 myotubes and caused increased expression of glucose transporter type 4 (GLUT4) and phosphoinositide 3-kinase (PI3K) genes suggesting that the compound can replace commercially available anti-diabetic drugs (Prabhakar and Doble, 2010).
MU: In your book you mention 2-deoxyglucose
as an adjunctive treatment to the CRKD.
Use of radiolabeled 2-deoxyglucose
may affect the suitability of this assay in a screening context.
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose
induces p53-dependent apoptosis in prostate cancer cells.
The first component is a modified glucose or sugar molecule called 2-deoxyglucose
, it fared well in early tests but was later found in animal studies to be toxic to the heart and to increase mortality.
Insulin-like growth factor I/somatomedin C action on 2-deoxyglucose
and a-amino isobutyrate uptake in chick embryo fibroblasts.
The effects of 2-deoxyglucose
and amino-oxyacetic acid on the radiation response of mammalian cells in vitro.
1998, "Citric acid production from cellulose hydrolysate by 2-deoxyglucose
resistant mutant strain of Aspergillus niger", Biores.
In addition, the Company has an ongoing Phase 2 clinical trial of glufosfamide in combination with gemcitabine for first-line treatment of advanced pancreatic cancer and a Phase 1 clinical trial of 2-Deoxyglucose
(2DG) for treatment of solid tumors.
They showed that acrylamide is produced when asparagine, an amino acid abundant in cereals and grains, is heated above 100 C with either of two sugars, glucose or 2-deoxyglucose