FUT1

(redirected from 2-alpha-L-fucosyltransferase)

FUT1

A gene on chromosome 19q13.3 that encodes a Golgi membrane protein involved in synthesising an H-antigen precursor, which is required for the final step in synthesising soluble A and B antigens. FUT1 is one of two genes that encode galactoside 2-L-fucosyltransferase.
 
Molecular pathology
FUT1 mutations cause the H-Bombay blood group.
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Recently, quantitative real-time reverse-transcription PCR analysis of glycosyltransferases in normal tissue, tissue from prostate cancer patients, and prostate cancer cell lines indicated that cancer cells have higher mRNA concentrations of Fut1 [fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)], which encodes fucosyltransferase, an enzyme responsible for [alpha]1-2 fucosylation (28).

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