2,3-diphosphoglycerate


Also found in: Wikipedia.

2,3-DPG

An inorganic phosphate produced in red cells by the Rapoport-Luebering shunt; 2,3-DPG binds to the beta chain of reduced haemoglobin (Hb), lowering Hb's affinity for O2 and by extension, facilitating O2 release to tissues, causing a "right shift" of the O2 dissociation curve. 2,3-DPG further shifts the curve to the right by lowering the red cells' pH, When transfused, red cells regain 50% of the 2,3-DPG within 3–8 hours and 100% within 24 hours.
Increased DPG High altitude, anaemia, chronic hypoxia, hyperthyroidism, chronic alkalosis
Decreased DPG Storage of blood, hypothyroidism, hypophosphatemia, acidosis

2,3-di·phos·pho·glyc·er·ate

(dī-fos'fō-glis'ĕr-āt)
An intermediate in the Rapoport-Luebering shunt, formed between 1,3-P2Gri and 3-phosphoglycerate; an important regulator of the affinity of hemoglobin for oxygen; an intermediate of phosphoglycerate mutase.

2,3-diphosphoglycerate

(dī″fŏs-fō-glĭs′ĕr-āt″),

2,3-DPG

An organic phosphate in red blood cells that alters the affinity of hemoglobin for oxygen. Blood cells stored in a blood bank lose 2,3-diphosphoglycerate, but once they are infused, the substance is resynthesized or reactivated.

2,3-diphosphoglycerate

References in periodicals archive ?
Effects of multibuffer supplementation on acid-base balance and 2,3-diphosphoglycerate following repetitive anaerobic exercise.
The so-called "red blood cell storage lesion" consists of several changes including oxidation, disruption of cellular structures, and loss of other chemicals such as the energy currency ATP and the hemoglobin regulator 2,3-diphosphoglycerate.
2]) should be used with caution, owing to the assumptions used with these calculations regarding normal 2,3-diphosphoglycerate concentrations and no abnormal hemoglobin.
Changes in shape, rigidity, depletion of 2,3-diphosphoglycerate (2,3 DPG), and nitric oxide scavenging are presumed to result in impaired perfusion and oxygen delivery (11), (12).
Restoration in vivo of erythrocyte adenosine triphosphate, 2,3-diphosphoglycerate, potassium ion, and sodium ion concentrations following the transfusion of acid-citrate-dextrose-stored human red blood cells.
Modulation of erythrocyte membrane mechanical stability by 2,3-diphosphoglycerate in the neonatal poikilocytosis/elliptocytosis syndrome.
The improvement of aerobic metabolism through phosphate loading is most likely caused by the impact of phosphates in the formation of 2,3-diphosphoglycerate (2,3-DPG), a compound in the red blood cells that facilitates the release of oxygen to the tissues.
The depletion of nitric-oxide bioactivity, along with the decrease in concentration of 2,3-diphosphoglycerate, or 2,3-DPG, both affect vasodilation, compromising oxygen delivery to tissues.
2,3) The oxygen affinity of human haemoglobin relies on adequate levels of 2,3-diphosphoglycerate compared with that of bovine haemoglobin, which is regulated by the concentration of chloride ions in the plasma.
Complications such as infections, immunosuppression, impairment of microcirculatory blood flow, 2,3-diphosphoglycerate deficiency, and an array of biochemical and physiological derangements including hypocalcemia, coagulopathy, hyperkalemia, and hypothermia are associated with the use of PRBCs.
studies of 2,3-diphosphoglycerate in solution and intact erythrocytes.
Delivoria-Pahadopoulos M, Roncevic NP, Oski FA, Postnatal changes in oxygen transport of term premature and sick infants : The role of red cell 2,3-diphosphoglycerate and adult hemoglobin, Pediatr.