2,3-bisphosphoglycerate


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2,3-bis·phos·pho·glyc·er·ate (2,3-P2Gri),

(bis-fos'fō-glis'er-āt),
An intermediate in the Rapoport-Luebering shunt, formed between 1,3-bisphosphoglycerate and 3-phosphoglycerate; an important regulator of the affinity of hemoglobin for oxygen; an intermediate of phosphoglycerate mutase.

2,3-bisphosphoglycerate

/2,3-bis·phos·pho·glyc·er·ate/ (bis-fos″fo-glis´er-āt) an intermediate in the conversion of 3-phosphoglycerate to 2-phosphoglycerate; it also acts as an allosteric effector in the regulation of oxygen binding by hemoglobin.

2,3-bis·phos·pho·glyc·er·ate

(bis'fos-fō-glis'ĕr-āt)
An intermediate in the Rapoport-Luebering shunt, formed between 1,3-bisphosphoglycerate and 3-phosphoglycerate; an important regulator of the affinity of hemoglobin for oxygen; an intermediate of phosphoglycerate mutase.
References in periodicals archive ?
The enzyme activity with other phosphorylated compounds such as adenosine 5'-triphosphate (ATP), adenosine 5'-monophosphate (AMP), ribose-5-phosphate, glucose-6-phosphate and 2,3-bisphosphoglycerate (2,3-BPG) was measured under the standard assay condition using 1 mM of each substrate.
The oxygen dissociation curve of normal hemoglobin represents the reaction of hemoglobin with oxygen as modified by hydrogen ions (Bohr effect) and 2,3-bisphosphoglycerate (BPG) (30, 31).
Decreased enzyme activity in the red blood cells reduces the glycolytic flow, with a moderate decrease of ATP (15% to 20%) and a more pronounced decrease of 2,3-bisphosphoglycerate (BPG) (about 50%).
Of note, according to the previous reports (Dragon and Baumann, 2003; LeonVelarde and Monge, 2004), the abilities of the elevated embryo mass in response to the gas exchange in hypoxia could increase the oxygen carrying capacity, decline the erythrocyte ATP level, early stimulate 2,3-bisphosphoglycerate (2,3-BPG) synthesis during embryonic development and promote oxygen utilization.

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