Insoluble metabolites such as uric acid, xanthine, and 2,8-dihydroxyadenine cause urinary tract calculi and arthritis.
2,8-Dihydroxyadenine was a kind gift of Ragnhild Seip (Oslo, Norway).
For succinyladenosine and 2,8-dihydroxyadenine, lower concentrations (7.
2-Deoxyadenosine, 2,8-dihydroxyadenine, and N-carbamyl-(3-amino-isobutyric acid were quantifiable up to 200 mmol/mol creatinine (100 [micro]mol/L) and succinyladenosine up to 140 mmol/mol creatinine (70 [micro]mol/L).
For xanthine, adenosine, 2,8-dihydroxyadenine, uracil, thymine, dihydrouracil, dihydrothymine, N-carbamyl-[beta]-amino-isobutyric acid, N-carbamyl-[beta]-alanine, uridine, and pseudouridine, the detection limit was between 1 and 10 [micro]mol/L.
2,8-Dihydroxyadenine (2,8-DHA) is excreted in urine and can precipitate in renal tissue and the urinary tract in patients with dihydroxyadeninuria attributable to adenine phosphoribosyltransferase (EC 2.
Adenine phosphoribosyltransferase deficiency: 2,8-dihydroxyadenine lithiasis.
For this reason, metabolites such as uric acid and 2,8-dihydroxyadenine are NMR invisible.
When the enzyme is deficient, adenine is not salvaged to AMP, but instead is oxidized to 8-hydroxyadenine and 2,8-dihydroxyadenine by xanthine dehydrogenase (XDH).
83 (d) 2,8-Dihydroxyadenine 1H-NMR invisible Guanine 8.