2,3-diphosphoglycerate

2,3-DPG

An inorganic phosphate produced in red cells by the Rapoport-Luebering shunt; 2,3-DPG binds to the beta chain of reduced haemoglobin (Hb), lowering Hb's affinity for O2 and by extension, facilitating O2 release to tissues, causing a "right shift" of the O2 dissociation curve. 2,3-DPG further shifts the curve to the right by lowering the red cells' pH, When transfused, red cells regain 50% of the 2,3-DPG within 3–8 hours and 100% within 24 hours.
Increased DPG High altitude, anaemia, chronic hypoxia, hyperthyroidism, chronic alkalosis
Decreased DPG Storage of blood, hypothyroidism, hypophosphatemia, acidosis

2,3-di·phos·pho·glyc·er·ate

(dī-fos'fō-glis'ĕr-āt)
An intermediate in the Rapoport-Luebering shunt, formed between 1,3-P2Gri and 3-phosphoglycerate; an important regulator of the affinity of hemoglobin for oxygen; an intermediate of phosphoglycerate mutase.

2,3-diphosphoglycerate

(dī″fŏs-fō-glĭs′ĕr-āt″),

2,3-DPG

An organic phosphate in red blood cells that alters the affinity of hemoglobin for oxygen. Blood cells stored in a blood bank lose 2,3-diphosphoglycerate, but once they are infused, the substance is resynthesized or reactivated.

2,3-diphosphoglycerate

References in periodicals archive ?
This might be explained by the fact that hypophosphataemia causes deficiency in the intermediary compounds for energy production such as adenosine triphosphate and 2,3-diphosphoglycerate and alterations in energy metabolism, which may lead to respiratory muscle weakness and consequent worsening of respiratory insufficiency.
Optimized hyperventilation preserves 2,3-diphosphoglycerate in severe traumatic brain injury.
A number of mechanisms have been proposed to provide benefit following SP ingestion which include an enhanced 2,3-diphosphoglycerate (2,3-DPG) concentration, which allows for greater unloading of oxygen to the peripheral tissues/muscle (Buck et al.
Effects of multibuffer supplementation on acid-base balance and 2,3-diphosphoglycerate following repetitive anaerobic exercise.
There is an elevation of 2,3-diphosphoglycerate (2,3-DPG) that is stimulated by a rise in intracellular pH.
2] with RBCT have been interpreted as a lack in transfusion effectiveness and are attributed to the loss of 2,3-diphosphoglycerate and nitric oxide during storage or to increased viscosity (23, 24).
The so-called "red blood cell storage lesion" consists of several changes including oxidation, disruption of cellular structures, and loss of other chemicals such as the energy currency ATP and the hemoglobin regulator 2,3-diphosphoglycerate.
2]) should be used with caution, owing to the assumptions used with these calculations regarding normal 2,3-diphosphoglycerate concentrations and no abnormal hemoglobin.
Changes in shape, rigidity, depletion of 2,3-diphosphoglycerate (2,3 DPG), and nitric oxide scavenging are presumed to result in impaired perfusion and oxygen delivery (11), (12).
Restoration in vivo of erythrocyte adenosine triphosphate, 2,3-diphosphoglycerate, potassium ion, and sodium ion concentrations following the transfusion of acid-citrate-dextrose-stored human red blood cells.
The depletion of nitric-oxide bioactivity, along with the decrease in concentration of 2,3-diphosphoglycerate, or 2,3-DPG, both affect vasodilation, compromising oxygen delivery to tissues.