S100A4

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S100A4

A gene on chromosome 1q21 that encodes a member of the S100 family of proteins, which have 2 EF-hand calcium-binding motifs. S100 proteins are localised in the cytoplasm and/or nucleus of a wide range of cells; they are involved in regulating cell cycle progression and differentiation and other intracellular activities. The S100A4-encoded protein is thought to play a role in motility, invasion and tubulin polymerisation.
 
Molecular pathology
S100A4 rearrangements have been implicated in tumour metastasis.
References in periodicals archive ?
For Group 18, classes 18A1 and 18A2 are Initial Exchangeable Certificates and Class 18A3, 18A4, 18A5 and 18A6 are Subsequent Exchangeable Certificate.
Centrin 1 (Cetn1) is a retroposon-derived gene, located on chromosome 18A2, that encodes a protein component of the centrosome.