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A precursor of the androgens, estrogens, and adrenocortical hormones. Its concentrations are elevated in 21-hydroxylase deficiency, a form of congenital adrenal hyperplasia.
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An earlier application of a second-tier test that several screening laboratories presently use for the detection of congenital adrenal hyperplasia cases is the liquid chromatography-MS/MS test designed to improve the selectivity for measuring 17a-hydroxyprogesterone and associated steroid hormones in the metabolic pathway (6).
In the same samples, TSH and 17-OHP were measured according to the instruction manuals of the dissociation-enhanced lanthanide fluorescence immunoassay (DELFIA[R]) test kits Neonatal 17a-hydroxyprogesterone and Neonatal hTSH (PerkinElmer).
Dehydroepiandrosterone, 17a-hydroxyprogesterone and aldosterone responses to the low-dose (1 micro g) ACTH test in subjects with preclinical adrenal autoimmunity.