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17-hydroxycorticosteroid |
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17-hydroxycorticosteroid
[-kôr′tikos′təroid] any steroid hydroxylated at carbon-17 secreted by adrenal glands and occasionally measured in the urine in a test for determining adrenal function and diagnosing hypoadrenalism or hyperadrenalism. The normal accumulation in the urine of men after 24-hour collection is 5.5 to 14.5 μg; in women, 4.9 to 12.9 μg; and in children, slightly less. The levels are normally two to four times higher in all cases after injection of 25 USP units of adrenocorticotropic hormone. 17-hydroxycorticosteroid Any of the steroid hormones synthesized in the adrenal gland by action of 17-hydroxylase–cortisol, cortisone, 11-deoxycortisol and tetrahydro derivatives; urine excretion of 17-OHCSs is a rough guide of
functional status of the adrenal gland and rate of catabolism ↑ in Pregnancy, Cushing's disease, obesity, pancreatitis ↓ in Addison's disease, hypopituitarism Ref range < age 1, 1.4-2.8 µmol/24–US: < 1 mg/24;
adult 8.2-27.6 µmol/24–US: 3-11 mg/24 Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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