15-hydroxyprostaglandin dehydrogenase

15-hy·drox·y·pros·ta·glan·din de·hy·dro·gen·ase

(hī-drok'sē-pros'tă-glan'din dē'hī-drō'jen-ās),
An enzyme that catalyzes the oxidation of prostaglandins, rendering them inactive, by converting the 15-hydroxyl group to a keto group using NAD+.
References in periodicals archive ?
Mutations in 15-hydroxyprostaglandin dehydrogenase cause primary hypertrophic osteoarthropathy.
Homozygous mutations in the 15-hydroxyprostaglandin dehydrogenase gene in patients with primary hypertrophic osteoarthropathy.
The researchers found that individuals whose colons had high levels of a specific gene product, 15-hydroxyprostaglandin dehydrogenase (15-PGDH) RNA, dramatically reduce their chances of developing colorectal cancer by taking aspirin, while analgesic provided no benefit to individuals whose colons showed low levels of 15-PGDH.