YWHAQ

(redirected from 14-3-3)

YWHAQ

A gene on chromosome 2p25.1 that encodes an adapter protein which regulates a broad spectrum of general and specialised signalling pathways by binding to a large number of partners, usually by recognising a phosphoserine or phosphothreonine motif. YWHAQ downregulates PDPK1’s kinase activity.
References in periodicals archive ?
Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease.
14-3-3 testing in diagnosing Creutzfeldt-Jakob disease.
Burkhard PR, Sanchez J-C, Landis T, Hochstrasser DE CSF detection of the 14-3-3 protein in unselected patients with dementia.
Detection of 14-3-3 protein in the cerebrospinal fluid supports the diagnosis of Creutzfeldt-Jakob disease.
Protein 14-3-3 (Centre for Research in Neurodegenerative Disease at the University of Toronto) was present in the CSF.
Thought to reflect neuronal injury, reported sensitivities and specificities of CSF protein 14-3-3 for CJD in patients with rapidly progressive dementia are 84%-96% and 87%-100%, respectively (15-21).
CSF protein 14-3-3 does not entirely rule out potentially treatable causes, and in this case an angiogram would likely not have been able to differentiate inflammatory from infectious vasculitis.