13-cis-retinoic acid

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13-cis-ret·i·no·ic ac·id

the retinoid most used in the U.S. to treat acne; it works by reducing sebum secretion. Use in pregnancy is contraindicated because of teratogenicity.
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References in periodicals archive ?
Beta carotene and 13-cis-retinoic acid both belong to a family of compounds known as the retinoids.
The new study represents the first long-term comparison of 13-cis-retinoic acid and beta carotene.
The patents describe methods of using 13-Cis-Retinoic Acid to treat three different medical conditions: 1) benign prostatic hyperplasia and other benign prostate conditions; 2) plantar and palmar fibrosis (Dupuytren's contracture); and 3) musculoskeletal and connective tissue inflammations including osteoarthritis and associated articular and periarticular inflammations, and non-articular Rheumatism.
Dr Veal and colleagues studied 70 patients receiving 13-cis-retinoic acid from hospitals around the UK and found that particularly in babies, where doses prescribed are often lower than those received by older children, levels of 13-cis-retinoic acid in the blood were frequently much lower than those thought to be effective.
This chapter is dense and goes into detail on the interactions of retinoids with the cell signalling pathways, the actions on growth factors and cytokines (including interferons whose successful action in the chemoprevention of head and neck carcinoma along with 13-cis-retinoic acid has been investigated).
Amanda Nelson, also from the Penn State group looked further into the question of how 13-cis-retinoic acid (13-cis-RA) causes sebaceous gland atrophy.