ALOX12

(redirected from 12-LOX)

ALOX12

A gene on chromosome 17p13.1 that encodes a member of the lipoxygenase (LOX) family of non-heme iron dioxygenases, which are involved in the production and metabolism of fatty acid hydroperoxidases.
References in periodicals archive ?
In conclusion, marked 12-LOX inhibition was demonstrated for two lichen metabolites that were previously known to have 5-LOX inhibitory activity.
The involvement of 12-LOX in malignant growth is suggested by overexpression in cancer cells and tissues and growth stimulation of malignant cell lines by 12-HETE (Natarajan and Nadler, 1998; Pidgeon et al.
To the best of our knowledge, this is the first report of lichen compounds being investigated for 12-LOX inhibitory properties.
In a recent speculative review Shureiqi and Lippman (2001) proposed that during carcinogenesis a shift occurs in a dynamic balance between different LOX pathways, towards the pro-carcinogenic 5-, 8- and 12-LOX pathways and away from the anti-carcinogenic 15-LOX pathway.
Based on the literature survey, their various pharmacological activities, such as antioxidation, inhibition of COX-1, COX-2, 5-LOX, 12-LOX, suppression of iNOS, cytosolic protein kinase C, and inhibition of platelet aggregation, are summarized in Table 1.
The reported activity of 18 prenylated flavonoids used in this study Compounds Source* Activity reported Flavones, Flavonols Morusin 1 Suppressor of iNOS, antinociceptive, platelet aggregation Kuwanon C 1 Inhibitor of 5-LOX, 12-LOX suppressor of iNOS Papyriflavonol A 2 Inhibitor of 5-LOX Flavanones 5-MSF B** 4 -- Kurarinone 4 Inhibitor of COX-1, 5-LOX, Inhibitor of [Ca.
These effects were diminished by PLA2 inhibitor (quinacrine), general LOX inhibitors (NDGA, ETYA), 5-LOX inhibitors (Rev 5901, AA861), 12-LOX inhibitor (baicalein) and FLAP inhibitor (MK886), while COX inhibitor (indomethacin) was without effect.
Therefore, knipholone showed higher affinity for the 5-LOX pathway than for cycloxygenases and 12-LOX.
In this study, we investigated the potential of 12-LOX as a predictor for the aggressiveness of prostate cancer.