11-dehydrocorticosterone | definition of 11-dehydrocorticosterone by Medical dictionary
one of the least active of the glucocorticosteroids produced by the adrenal cortex; it affects water and salt metabolism.
A metabolite of corticosterone.
11-dehydrocorticosterone /11-de·hy·dro·cor·ti·cos·ter·one/ (-kor″tĭ-kos´ter-ōn) a steroid produced by the adrenal cortex.
A metabolite of corticosterone, found in the cortex of the suprarenal gland.
one of the least active of the glucocorticosteroids produced by the adrenal cortex.
References in periodicals archive
In the placenta the fetus is protected from the high maternal glucocorticoid concentration through the activity of 11[beta]-hydroxysteroid dehydrogenase type 2 (11[beta]-HSD2), which converts active 11[beta]-hydroxyglucocorticoids (cortisol in human, corticosterone in rodents) into inactive 11-ketoglucocorticoids (cortisone in human, 11-dehydrocorticosterone
in rodents) (reviewed in Stewart and Krozowski 1999).
The enzyme 11[beta]-hydroxysteroid dehydrogenase type 2 (11[beta]-HSD2) converts corticosterone to 11-dehydrocorticosterone
in the distal convoluted tubules and cortical collecting ducts in rats, and cortisol to cortisone in humans.
Improved determination of urinary cortisol and cortisone, or corticosterone and 11-dehydrocorticosterone
by high-performance liquid chromatography with ultraviolet absorbance detection.
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