1-alpha-hydroxylase

1-alpha-hydroxylase

the renal enzyme which participates in the conversion of 1,25-hydroxycholecalciferol into 1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol.
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Here it is hydroxylated by another enzyme, 1-alpha-hydroxylase, to create the biologically active form of vitamin D, 1,25-dihydroxycholecalciferol or calcitriol.