calcitriol

(redirected from 1,25-dihydroxycholecalciferol)
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calcitriol

 [kal´sĭ-tri´ol]
1,25-dihydroxycholecalciferol; a form of vitamin D used as a calcium regulator in the management of hypocalcemia in conditions such as rickets, osteodystrophy, hypoparathyroidism, and complications of renal dialysis; administered orally or intravenously.

cal·ci·tri·ol

(kal'si-trī'ol),
1α,25-Dihydroxycholecalciferol (thus, a 1,3,25-triol); formation of calcitriol is the second step in the biologic conversion of vitamin D3 to its active form; it is more potent than calcidiol.

calcitriol

/cal·ci·tri·ol/ (kal″sĭ-tri´ol)
2. a preparation of this compound, used in the treatment of hypocalcemia, hypophosphatemia, rickets, and osteodystrophy associated with a variety of disorders.

calcitriol

[kalsit′rē·ôl]
the active form of vitamin D, a regulator of calcium metabolism.
indication It is prescribed in the management of hypocalcemia in patients undergoing chronic renal dialysis and in patients with hypoparathyroidism.
contraindications Hypercalcemia, evidence of vitamin D toxicity, malabsorption syndrome, decreased renal function, or known sensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse reactions are renal toxicity and those associated with hypercalcemia, such as soft tissue calcification.

calcitriol

A form of vitamin D3 which promotes intestinal absorption of Ca2+, increases renal tubular reabsorption of Ca2+ and reduces Ca2+ resorption by bone.
 
Indications
Postmenopausal and corticosteroid-induced osteoporosis, hypocalcaemia, hypoparathyroidism, osteomalacia, rickets, renal osteodystrophy, chronic renal dialysis.

Adverse effects
Nausea, vomiting, constipation, anorexia, headache, thirst, sweating, polyuria—all due to hypercalcaemia.

calcitriol

A vitamin D analogue drug used in the treatment of low calcium levels resulting from kidney disease. Brand names are Calcijex, Rocatrol and Silkis.

calcitriol

vitamin D derivative used to treat vitamin D deficiency, postmenopausal osteoporosis and rickets

calcitriol (kal´sitri´ol),

n brand name: Calcijex;
drug class: vitamin D3 hormone;
action: increases intestinal absorption of calcium and phosphorus;
uses: hypocalcemia in chronic renal dialysis and rickets, nutritional supplement.

calcitriol

a nonproprietary name for 1,25-dihydroxycholecalciferol; used as a calcium regulator in the management of hypocalcemia.
References in periodicals archive ?
Women lose bone calcium rapidly in the post--menopausal years, because of age--related changes in parathyroid hormone, 1,25-dihydroxycholecalciferol and estrogen levels which predispose them to osteoporosis (Pinn, 1991).
3]) in the liver and subsequently into its active metabolite 1,25-dihydroxycholecalciferol (1,25[(OH).
The physiologic roles of calcium, magnesium, and 1,25-dihydroxycholecalciferol (the active metabolite of vitamin [D.
Here it is hydroxylated by another enzyme, 1-alpha-hydroxylase, to create the biologically active form of vitamin D, 1,25-dihydroxycholecalciferol or calcitriol.
Associations between age, blood lead, and serum 1,25-dihydroxycholecalciferol levels in children.
Vitamin D is a membrane antioxidant: thus Vitamin D3 (cholecalciferol) and its active metabolite 1,25-dihydroxycholecalciferol and also Vitamin D2 (ergocalciferol) and 7-dehydrocholesterol (pro-Vitamin D3) all inhibited iron-dependent liposomal lipid peroxidation.
All-trans retinoic acid antagonizes the action of calciferol and its active metabolite, 1,25-dihydroxycholecalciferol, in rats.
Multicentre comparison of 1,25-dihydroxycholecalciferol measurements in human serum.