calcitriol(redirected from 1,25-dihydroxy vitamin D)
Also found in: Dictionary, Encyclopedia.
1α,25-Dihydroxycholecalciferol (thus, a 1,3,25-triol); formation of calcitriol is the second step in the biologic conversion of vitamin D3 to its active form; it is more potent than calcidiol.
1. see dihydroxycholecalciferol.
the active form of vitamin D, a regulator of calcium metabolism.
indication It is prescribed in the management of hypocalcemia in patients undergoing chronic renal dialysis and in patients with hypoparathyroidism.
contraindications Hypercalcemia, evidence of vitamin D toxicity, malabsorption syndrome, decreased renal function, or known sensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse reactions are renal toxicity and those associated with hypercalcemia, such as soft tissue calcification.
calcitriolA form of vitamin D3 which promotes intestinal absorption of Ca2+, increases renal tubular reabsorption of Ca2+ and reduces Ca2+ resorption by bone.
Postmenopausal and corticosteroid-induced osteoporosis, hypocalcaemia, hypoparathyroidism, osteomalacia, rickets, renal osteodystrophy, chronic renal dialysis.
Nausea, vomiting, constipation, anorexia, headache, thirst, sweating, polyuria—all due to hypercalcaemia.
calcitriolA vitamin D analogue drug used in the treatment of low calcium levels resulting from kidney disease. Brand names are Calcijex, Rocatrol and Silkis.
a nonproprietary name for 1,25-dihydroxycholecalciferol; used as a calcium regulator in the management of hypocalcemia.